Fan Lihong is the chief physician and PhD graduate mentor of the Second Affiliated Hospital of Xi'an Jiaotong University, as well as serving as the associate director of the operations and Management Department of this hospital.
Dr. Fan serves as the committee member in several physician associations, including the shoulder and elbow surgery section of the Chinese Medical Association, the osteoarthritis Working Committee of the Chinese Medical Association, the spine endoscopy group of the orthopedic Specialty Committee of the Chinese medical Promotion Association, the arthroscopy group of the joint surgery section of Shaanxi Province, and the spine surgery section of Shaanxi Province.
He has spent many visits to the well-known medical institutions such as the stem cell research center of Yang Ming University in Taiwan, the Nepean hospital in Australia, the joint replacement center in Texas, USA, and the ameos hospital in Berlin, Germany for his study. Invited to give special presentations and mural exchanges at the 2015 World Congress on arthroplasty, the Asian joint annual meeting.
He has published more than 20 papers in international prominent medical journals such as bone, scientific reports, Journal of vascular surgery, hosted two National Natural Science Foundation of China, participated in research on multiple topics, and participated in three monographs of translational medicine.
Dr. Fan's laboratory studies three directions: sports medicine and arthroscopic surgery, bone and joint repair reconstruction, artificial joint replacement and revision.
Hosting research topics:
1. HIF-1 α And BMP-7 cotransfection with MSCs transplantation for osteonecrosis of the femoral head: an experimental study (National Natural Science Foundation of China young program)
2. 3D microstructure printing lithium incorporation β- Treatment of osteonecrosis of the femoral head by transfection of mesenchymal stem cells with TCP compounded with microRNA-21 (National Natural Science Foundation of China - facial project 81572145)
3. Mir-210-modified BMMSCs derived exosomes composite injectable hydrogel activates PI3K / Akt pathway to treat steroid induced osteonecrosis of the femoral head (National Natural Science Foundation of China - facepiece project 81772355)
Academic and scientific findings:
Fan LH, Wang KZ, Cheng B, Wang CS, Dang XQ. Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.BMC Neurosci. 2006 Jun 14;7:48.
Die J, Wang K, Fan L, Jiang Y, Shi Z. Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions.Brain Res. 2010 Jul 30;1346:251-61.
Liu C, Shi Z, Fan L, Zhang C, Wang K, Wang B. Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury.Brain Res. 2011 Feb 16;1374:100-9.
Fan L, Wang K, Shi Z, Die J, Wang C, Dang X. Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.J Vasc Surg. 2011 Jul;54(1):192-200.
Fan L, Dang X, Shi Z, Zhang C, Wang K. Hydroxysafflor yellow A protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation.Cell Mol Neurobiol. 2011 Nov;31(8):1187-94.
Fan L, Dang X, Wang K. Comparison between bipolar hemiarthroplasty and total hip arthroplasty for unstable intertrochanteric fractures in elderly osteoporotic patients.PLoS One. 2012;7(6):e39531.
Zhang C, Ma J, Fan L, Zou Y, Dang X, Wang K, Song J. Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating. Tissue Cell. 2015 Jun;47(3):291-300.
Yu Z, Fan L, Li J, Ge Z, Dang X, Wang K. Lithium chloride attenuates the abnormal osteogenic/adipogenic differentiation of bone marrow-derived mesenchymal stem cells obtained from rats with steroid-related osteonecrosis by activating the β-catenin pathway.Int J Mol Med. 2015 Nov;36(5):1264-72.
Fan L, Zhang C, Yu Z, Shi Z, Dang X, Wang K. Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and osteogenesis in rabbit femoral head osteonecrosis. Bone. 2015 Dec;81:544-53.
Pei JP, Fan LH(*), Nan K1, Li J, Dang XQ, Wang KZ. HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury.J Neuroinflammation. 2017 May 3;14(1):97.
Pei J, Fan L, Nan K, Li J, Shi Z, Dang X, Wang K. Excessive Activation of TLR4/NF-κB Interactively Suppresses the Canonical Wnt/β-catenin Pathway and Induces SANFH in SD Rats.Sci Rep. 2017 Sep 20;7(1):11928
Nan Kai, Pei Jun-Peng, Fan Li-Hong et al. Resveratrol prevents steroid-induced osteonecrosis of the femoral head via miR-146a modulation.[J] .Ann N Y Acad Sci, 2021, 1503: 23-37.
Nan Kai, Zhang Yuankai, Fan Li-Hong et al. Exosomes from miRNA-378-modified adipose-derived stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by enhancing angiogenesis and osteogenesis via targeting miR-378 negatively regulated suppressor of fused (Sufu).[J] .Stem Cell Res Ther, 2021, 12: 331.
